ITPKA (inositol-trisphosphate 3-kinase A)

ITPKA DrugBank Gene Name P23677 UniProt Accession 3706 Entrez Gene Id Gene Info: Publications: Overington et al., 2006, How many drug targets are there?, Nat Rev Drug

ITPKA gene, which is located in 15q15, encodes a predicted 461 amino acid polypeptide. Under physiological conditions, ITPKA is only identified in neurons and testis [ 6 ]. Plasmid pCNL-N1_ITPKA from Dr. Yasushi Okada's lab contains the insert inositol triphosphate 3-kinase A and is published in Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112.

ITK is This 12-sample array allows analysis of genetic and structural variation in the human genome, such as duplications, deletions, amplifications, copy-neutral LOH, Learn about mechanism of action for PIQRAY. PIK3CA is the most commonly mutated gene in HR+/ HER2- aBC. See full Prescribing and Safety Info. 7 Jul 2020 (Prokka is a microbial genome annotation tool written in Perl). Genes are first identified with prodigal and the open reading frames blasted in turn ResolveDNA whole genome sequencing solutions provide a clear advantage. genome amplification (WGA), called Primary Template-directed Amplification CGIAR genebanks conserve collections of plant genetic resources for food and agriculture (PGRFA).

ITPKA is a potential oncogene that it is overexpressed in most tumors, and its overexpression promotes tumorigenesis. ITPKA gene body methylation regulates its expression and thus serves as a novel and potential biomarker for early cancer detection.

PTHLH suppresses expression of neuronal genes in nonneuronal tissues, regulates expression of ITPKA. Knockdown of REST/NRSF induced expression of ITPKA in 5 Mar 2021 ITPKA (Inositol-Trisphosphate 3-Kinase A) is a Protein Coding gene. Among its related pathways are superpathway of inositol phosphate 2 May 2019 Filtering for genes in which 3'UTR DNA methylation strongly correlated with Methylation of the ITPKA gene body is associated with increased (B) Fold change of mRNA expression of genes with DNA hypermethylated DMRs following BDPP administration; GRB10,. RGS9, ITPKA, NDUFB9, CAMK2A, 15 Oct 2020 ITPKA promotes RCC growth, migration and invasion in cultured cells, in The Cancer Genome Atlas (TCGA), and screened out ITPKA gene 10 Dec 2019 HD-related genes (e.g., Penk, Plk5, Itpka), despite being downregulated Correlative patterns between phenotype and gene expression.

Itpka MGI Mouse Gene Detail - MGI:1333822 - inositol 1,4,5-trisphosphate 3-kinase A. View mouse Itpka Chr2:119742337-119751253 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression. Home.

Wang YW, Ma X, Zhang YA, Wang MJ, Yatabe Y, Lam S, Girard L, Chen JY, Gazdar AF The C-terminal part of ITPKB, namely residues 187 to 462, was 68% identical to ITPKA in amino acid sequence. Mapping By in situ hybridization, Erneux et al. (1992) mapped the ITPKB gene to 1q41-q43. Plasmid ITPKA_3xmScarletI from Dr. Dorus Gadella's lab contains the insert ITPKA and is published in bioRxiv 160374 This plasmid is available through Addgene. ITPKA gene, which is located in 15q15, encodes a predicted 461 amino acid polypeptide. Under physiological conditions, ITPKA is only identified in neurons and testis [ 6 ].

ITPKA has 3,320 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 82 datasets. Gene symbol: ITPKA: Gene name: inositol-trisphosphate 3-kinase A: Chromosome: 15: Chromosomal band: q15.1: Imprinted: Unknown: Genomic reference: NC_000015.9: Transcript reference: NM_002220.2: Associated with diseases-Citation reference(s)-Curators (1) Global Variome, with Curator vacancy: Total number of public variants reported: 3: Unique ITPK1 (Inositol-Tetrakisphosphate 1-Kinase) is a Protein Coding gene. Diseases associated with ITPK1 include Neural Tube Defects.Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Inositol phosphate metabolism.Gene Ontology (GO) annotations related to this gene include magnesium ion binding and inositol tetrakisphosphate 1-kinase activity. Plasmid ITPKA_3xmScarletI from Dr. Dorus Gadella's lab contains the insert ITPKA and is published in bioRxiv 160374 This plasmid is available through Addgene. Predicted to have inositol hexakisphosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process and phosphatidylinositol phosphorylation. Predicted to localize to cytoplasm and nucleus.
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We showed that ITPKA expression is up-regulated in many forms of cancers, including lung and breast cancers, and that overexpressed ITPKA contributes to tumorigenesis. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and inositol tetrakisphosphate 1-kinase activity. UniProtKB/Swiss-Prot Summary for ITPK1 Gene Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. ITPKA Antibodies Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Summary of ITPKA expression in human tissue.
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Figure 1 ITPKA is screened out as a promoter in RCC and positively correlated with RCC malignancy and poorer prognosis. (A) Schematic diagram of screening strategy.(B) A volcano plot illustrating differentially regulated gene expression from RNA-seq analysis between the normal and tumor tissues.

Predicted to have inositol hexakisphosphate kinase activity. Predicted to be involved in inositol phosphate biosynthetic process and phosphatidylinositol phosphorylation. Predicted to localize to cytoplasm and nucleus. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). ITPKA is expressed in a broad range of tumor types but shows limited expression in normal cells.

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Summary: Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling.

Inositol-trisphosphate 3-kinase A gene (ITPKA), a kinase 5 Jan 2021 In contrast, ITPKA is expressed primarily in neurons, while ITPKC expression is restricted to glia (27). qPCR analysis of ITPKA, ITPKB, and ITPKC In lung and breast cancer expression of ITPKA is stimulated by gene body methylation which 23 Feb 2021 GAPDH gene was the internal control for ITPKA. Primers for ITPKA was designed based on GenBank reference sequence (Genebank Key Words: Human cumulus cell, gene expression, oocyte quality, pregnancy, live birth and HSD3B1) and the calcium-related genes (TRPM7, ITPKA,.